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Personal Information

Name SASAZUKI Takehiko Sasazuki Takehiko
Section Section II, Seventh Subsection
Date of Election 2019/12/12
Speciality Immunology, Immunogenetics, Human Genetics
Selected Bibliography
  1. Sasazuki T, McDevitt HO, and Grumet FC. The association between genes in the major histocompatibility complex and disease susceptibility. Annual Review of Medicine, 28: 425-452, 1977.
  2. Sasazuki T, Kohno Y, Iwamoto I, Tanimura M, Naito S. Association between an HLA haplotype and low responsiveness to tetanus toxoid in man. Nature, 272: 359-361, 1978.
  3. Uno H, Sasazuki T, Tamai H, Matsumoto H. Two major genes, linked to HLA and Gm, control susceptibility to Graves' disease. Nature, 292: 768-770, 1981.
  4. Nishimura Y, Sasazuki T. Suppressor T cells control the HLA-linked low responsiveness to streprococcal antigen in man. Nature, 302: 67-69, 1983.
  5. Hirayama K, Matsushita S, Kikuchi I, Iuchi M, Ohta N, Sasazuki T. HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans. Nature, 327: 426-430, 1987.
  6. Harada F, Kimura A, Iwanaga T, Shimozawa K, Yata J, Sasazuki T. Gene conversion-like events cause steroid 21-hydroxylase deficiency in congenital adrenal hyperplasia. Proc. Natl. Acad. Sci. USA., 84: 8091-8094, 1987.
  7. Okamoto N, Sasaki M, Sugio K, Sato C, Iwama T, Ikeuchi T, Tonomura A, Sasazuki T, Miyaki M. Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli. Nature (Lond.) 331:273-277: 1988.
  8. Shirasawa S, Furuse M, Yokoyama N, Sasazuki T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science, 260: 85-88, 1993.
  9. Fukui Y, Ishimoto T, Utsuyama M, Gyotoku T, Koga T, Nakao K, Hirokawa K, Katsuki M, Sasazuki T. Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus. Immunity, 6: 401-410, 1997.
  10. Sasazuki T, Juji T, Morishima Y, Kinukawa N, Kashiwabara H, Inoko H, Yoshida T, Kimura A, Akaza T, Kamikawaji N, Kodera Y, Takaku F. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. New Engl. J. Med., 339:1177-1185, 1998.
  11. Fukui Y, Hashimoto O, Sanui T, Oono T, Koga H, Abe M, Inayoshi A, Noda M, Oike M, Shirai T, Sasazuki T. Hematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature, 412: 826-831, 2001.
  12. Sanui T, Inayoshi A, Noda M, Iwata E, Oike M, Sasazuki T, Fukui Y. DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-θ and LFA-1, in T cells. Immunity, 19: 119-129, 2003.
  13. Tanaka Y, Hamano S, Gotoh K, Murata Y, Kunisaki Y, Nishikimi A, Takii R, Kawaguchi M, Inayoshi A, Sasazuki T, Fukui Y. T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock2. Nat. Immunol., 8(10):1067-1075, 2007.
  14. Ueda S, Oryoji D, Yamamoto K, Noh JY, Okamura K, Noda M, Kashiwase K, Kosuga Y, Sekiya K, Inoue K, Yamada H, Oyamada A, Nishimura Y, Yoshikai Y, Ito K, Sasazuki T. Identification of independent susceptible and protective HLA alleles in Japanese autoimmune thyroid disease and their epistasis. J. Clin. Endocrinol. Metab., 99(2):E379-383, 2014.
  15. Morishima Y, Kashiwase K, Matsuo K, Azuma F, Morishima S, Onizuka M, Yabe T, Murata M, Doki N, Eto T, Mori T, Miyamura K, Sao H, Ichinohe T, Saji H, Kato S, Atsuta Y, Kawa K, Kodera Y, Sasazuki T. Biological significance of HLA locus matching in unrelated donor bone marrow transplantation. Blood, 125(7):1189-1197, 2015.

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