The Japan Academy

Personal Information

 

Name

OHTSUKA Eiko

OHTSUKA Eiko

 

Section

Section II, Seventh Subsection

Date of Election

2020/12/14

Speciality

Nucleic Acids Chemistry

Selected Bibliography

Books and Reviews

  1. 池原森男，上田　亨，大塚栄子：核酸有機化学、化学同人、京都、1979.
  2. Ohtsuka, E: Non-canonical hydrogen bonds in genetic information flow, Proceedings of the Japan Academy, Ser. B, 81：393-402, 2005.
  1. Ohtsuka, E, Tanaka, S, Tanaka, T, Miyake, T. Markham, AF, Nakagawa, E, Wakabayashi, T, Taniyama, Y, Nishikawa, S, Fukumoto, R, Uemura, H, Doi, T, Tokunaga, T, and Ikehara, M: Total synthesis of a RNA molecule with sequence identical to that of Escherichia coli formylmethionine tRNA, Proc. Natl. Acad. Sci. USA, 78: 5493-5497, 1981.
  2. Uemura, H, Imai, M, Ohtsuka, E, Ikehara, M and Söll, D: E. coli initiator tRNA analogs with different nucleotides in the discriminator base position, Nucleic Acids Res., 10: 6531-6539, 1982.
  3. Ohtsuka, E, Matsuki, S, Ikehara, M, Takahashi, Y, and Matsubara, K: An alternative aproach to deoxyoligonucleotides as hybridization probes by insertion of deoxyinosine at ambiguous codon positions, J. Biol. Chem., 260: 2605-2608, 1985.
  4. Takahashi, Y, Kato, K, Hayashizaki, Y, Wakabayashi, T, Ohtsuka, E, Matsuki, S, Ikehara,   M, and Matsubara, K: Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine, Proc. Natl.Acad. Sci. USA, 82: 1931-1935, 1985.
  5. Inoue, H, Hayase, Y, Iwai, S, and Ohtsuka, E: Sequence-dependent hydrolysis of RNA using modified oligonucleotide splints and RNase FEBS Lett., 215: 327-330, 1987.
  6. Hayase, Y, Jahn, M, Rogers, MJ, Sylvers, LA, Koizumi, M, Inoue, H, Ohtsuka, E, and   Söll, D: Recognition of bases in Escherichia coli tRNAGln by glutaminyl-tRNA synthetase: a complete identity set, EMBO J., 11: 4159-4165, 1992.
  7. Koizumi, M, Hayase, Y, Iwai, S, Kamiya, H, Inoue, H and Ohtsuka, E: Design of RNA enzymes distinguishing a single base mutation in RNA, Nucleic Acids Res., 17: 7059-7071, 1989.
  8. Koizumi, M, Kamiya, H, and Ohtsuka, E: Ribozymes designed to inhibit transformation of NIH3T3 cells by the activated c-Ha-ras gene, Gene, 117: 179-184, 1992.
  9. Iwai, S, Shimizu, M, Kamiya, H, and Ohtsuka. E: Synthesis of a phosphoramidite coupling unit of the pyrimidine (6-4) pyrimidone photoproduct and its incorporation into oligodeoxynucleotides, J. Am. Chem. Soc. 118: 7642-7643, 1996.
  10. Kamiya, H, Miura, K, Ohtomo, N, Koda, T, Kakinuma, M, Nishimura S, and Ohtsuka, E: Transformation of NIH3T3 cells with synthetic c-Ha-ras genes, Jpn. J. Cancer Res., 80: 200-203, 1989.
  11. Kamiya, H, Miura, K, Ishikawa, H, Inoue, H, Nishimura, S, and Ohtsuka, E: c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions, Cancer Res., 52: 3483-3485, 1992.
  12. Kamiya, H, Murata, N, Murata, T, Iwai, S, Matsukage, A, Masutani, C, Hanaoka, F, and  Ohtsuka, E: Cyclobutane thymine dimers in a ras proto-oncogene hot spot activate the gene by point mutation, Nucleic Acids Res., 21: 2355-2361, 1993.
  13. Kuchino, Y, Mori, F, Kasai, H, Inoue, H, Iwai, S, Miura, K, Ohtsuka, E, and Nishimura, S: Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues, Nature, 327: 77-79, 1987.
  14. Ikehara, M, Ohtsuka, E, Tokunaga, T, Taniyama, Y, Iwai, Kitano, K, Miyamoto, S. Ohgi, T, Sakuragawa, Y, Fujiyama, K, Ikari, Kobayashi, T, Miyake, T, Shibahara, S, Ono, A, Ueda, T, Tanaka, T, Baba, H, Miki, T, Sakurai, A, Oishi, T, Chisaka, O. and Maysubara, K: Synthesis of a gene for human growth hormone and its expression in Escherichia coli, Proc. Natl.Acad. Sci. USA, 81: 5956-5960, 1984.
  15. Miura, K, Inoue, H, Nakamori, H, Iwai, S, Ohtsuka, E, Ikehara, M, Noguchi,S, and  Nishimura, S: Synthesis and expression of a synthetic gene for the activated human c-Ha-ras protein, Jpn. J. Cancer Res., 77: 45-51,1986.
  16. de Vos, AM, Tong, L, Milburn, MV, Matias, PM,  Jancarik, J, Noguchi, S, Nishimura, S, Miura, K, Ohtsuka, E and Kim, S-H: Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21, Science, 239:888-893, 1988.
  17. Morikawa, K, Matsumoto, O, Tsujimoto, M, Katayanagi,K, Ariyohsi, M, Doi, T,Ikehara, M, Inaoka, T, and Ohtsuka, E: X-ray structure of T4 endonuclease V: An excision repair enzyme specific for a pyrimidine dimer, Science, 256: 523-526, 1992.
  18. Vassylyev, DG, Kashiwagi, T, Mikami, Y, Ariyahsi, M, Iwai, S, Ohtsuka, E, and Morikawa, K: Atomic model of a pyrimidine dimer excision complexed with a DNA substrate: structural basus for damaged DNA recognition, Cell, 83: 773-782, 1995.