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Personal Information

Name Kishimoto Tadamitsu Kishimoto, Tadamitsu
Section Section II, Seventh Subsection
Date of Election 1995/12/12
Speciality Immunology
Selected Bibliography
    1. Hirano, T., K. Yasukawa, H. Harada, T. Taga, Y. Watanabe, T. Matsuda, S. Kashiwamura, K. Nakajima, K. Koyama, A. Iwamatsu, S. Tsunasawa, F. Sakiyama, H. Matsui, Y. Takahara, T. Taniguchi, and T. Kishimoto. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324: 73-76, 1986.
    2. Kawano, M., T. Hirano, T. Matsuda, T. Taga, Y. Horii, K. Iwato, H. Asaoku, B. Tang, O. Tanabe, H. Tanaka, A. Kuramoto, and T. Kishimoto. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332: 83-85, 1988.
    3. Yamasaki, K., T. Taga, Y. Hirata, H. Yawata, Y. Kawanishi, B. Seed, T. Taniguchi, T. Hirano, and T. Kishimoto. Cloning and expression of human interleukin 6 (BSF-2/IFNb2) receptor. Science 241: 825-828, 1988.
    4. Taga, T., M. Hibi, Y. Hirata, K. Yamasaki, K. Yasukawa, T. Matsuda, T. Hirano, and T. Kishimoto. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58: 573-581, 1989.
    5. Hibi, M., M. Murakami, M. Saito, T. Hirano, T. Taga, and T. Kishimoto. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63: 1149-1157, 1990.
    6. Akira, S., H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajima, T. Hirano, and T. Kishimoto. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 9: 1897-1906, 1990.
    7. Akira, S., Y. Nishio, M. Inoue, X. Wang, S. Wei, T. Matsusaka, K. Yoshida, T. Sudo, M. Naruto, and T. Kishimoto. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77: 63-71, 1994.
    8. Naka, T., M. Narazaki, M. Hirata, T. Matsumoto, S. Minamoto, A. Aono, N. Nishimoto, T. Kajita, T. Taga, K. Yoshizaki, S. Akira, and T. Kishimoto. Structure and function of a new STAT-induced STAT inhibitor-1. Nature 387: 924-929, 1997.
    9. Nishimoto, N., M. Sasai, Y. Shima, M. Nakagawa, T. Matsumoto, T. Shirai, T. Kishimoto, and K. Yoshizaki. Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy. Blood 95: 56-61, 2000.
    10. Nishimoto, N., K. Yoshizaki, N. Miyasaka, K. Yamamoto, S. Kawai, T. Takeuchi, J. Hashimoto, J. Azuma, and T. Kishimoto. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 50: 1761-1769, 2004.
    11. Yokota, S., T. Miyamae, T. Imagawa, N. Iwata, S. Katakura, M. Mori, P. Woo, N. Nishimoto, K. Yoshizaki, and T. Kishimoto. Therapeutic efficacy of humanized recombinant anti-IL-6 receptor antibody for children with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 52: 818-825, 2005.
    12. Kishimoto, T. Interleukin-6: From basic science to medicine, 40 years in immunology. Annu. Rev. Immunol. 23: 1-21, 2005.
    13. Tanaka, T., Narazaki, M., and Kishimoto, T. IL-6 in inflammation, immunity, and disease. Cold Spring Harbor Perspective Biol. 6, 2014.
    14. Higa, M., Oka, M., Fujihara, Y., Masuda, K., Yoneda, Y., and Kishimoto, T. Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a. Proc. Natl. Acad. Sci. USA 115(6): E1214-E1220, 2018.
    15. Gemechu, Y., Millrine, D., Hashimoto, S., Prakash, J., Sanchenkova, K., Metwally, H., Gyanu, P., Kang, S.J., and Kishimoto, T. Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs. Proceedings of the National Academy of Sciences of the United States of America 115: 11802-11807, 2018.

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