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Personal Information

Name AKIRA, Shizuo Akira, Shizuo
Section Section II, Seventh Subsection
Date of Election 2014/12/12
Speciality

Immunology

Selected Bibliography
    1. Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K. and Akira, S. Cutting Edge: Toll-like receptor 4(TLR4)-deficient mice is hyporesponsive to LPS: evidence for TLR4 as the Lps gene product. J Immunol. 162: 3749-3752, 1999.
    2. Kawai, T., Adachi, O., Ogawa, T., Takeda, K. and Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity. 11: 115-122, 1999.
    3. Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K. and Akira, S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 11: 443-451, 1999.
    4. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K. and Akira, S. A Toll-like receptor recognizes bacterial DNA. Nature. 408: 740-745, 2000.
    5. Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T., Takeda, K. and Akira, S. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature. 420: 324-329, 2002.
    6. Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K. and Akira, S. Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science. 301: 640-643, 2003.
    7. Akira, S., Uematsu, S. and Takeuchi, O. Pathogen recognition and innate immunity. Cell. 24: 783-801, 2006.
    8. Matsushita, K., Takeuchi, O., Standley, D. M., Kumagai, Y., Kawagoe, T., Miyake, T., Stoh, T., Kato, H., Tsujimura, T., Nakamura, H. and Akira, S. Zc3h12a is an Rnase essential for controlling immune responses by regulating mRNA decay. Nature. 458: 1185-1190, 2009.
    9. Satoh, T., Kidoya, H., Naito, H., Yamamoto, M., Takemura, N., Nakagawa, K., Yoshioka, Y., Morii, E., Takakura, N., Takeuchi, O. and Akira, S. Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages. Nature. 495: 524-528, 2013.
    10. Uehata, T., Iwasaki, H., Vandenbon, A., Matsushita, K., Hernandez-Cuellar, E., Kuniyoshi, K., Satoh, T., Mino, T., Suzuki, Y., Standley, D.M., Tsujimura, T., Rakugi, H., Isaka, Y., Takeuchi, O. and Akira, S. Malt1-induced cleavage of Regnase-1 in CD4+ helper T cells regulates immune activation. Cell. 153: 1036-1049, 2013.

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