日本学士院

会員情報

 

氏名

喜田宏 （きだ　ひろし）

 

所属部・分科

第2部第6分科

選定年月日

平成19年12月12日

専攻学科目

獣医微生物学

現職等

北海道大学ユニバーシティプロフェッサー
北海道大学人獣共通感染症リサーチセンター特別招聘教授・統括
WHO指定人獣共通感染症対策研究協力センター長
北海道大学名誉教授

受賞等

〔国内〕

日本獣医学会賞（昭和57年）
北海道科学技術賞（平成14年）
北海道新聞文化賞（平成16年）
日本農学賞・読売農学賞（平成17年）
日本学士院賞（平成17年）
瑞宝重光章（平成29年）
文化功労者（平成29年）
日本ワクチン学会 高橋賞（令和元年）

〔海外〕

外国アカデミー会員等

タイ王国 タマサート大学 名誉博士（公衆衛生学）（平成29年）

主要な学術上の業績

喜田　宏氏は、インフルエンザの疫学研究を地球規模で行い、ウイルスの遺伝子解析と感染実験の結果、夏にカモが営巣するシベリアの湖沼水中に存続しているウイルスが、渡りガモによって中国南部の池に持ち込まれ、そこでアヒル等を介してブタに伝播する経路を明らかにしました。さらに、ヒトと鳥のインフルエンザウイルスに同時感染したブタの呼吸器で新型ウイルスが出現する機構を実証しました。

また喜田氏は、ウイルスの宿主域、病原性と抗原変異などの現象が、ウイルスと宿主細胞の遺伝子やタンパク質分子間の相互作用によって起こることを明らかにしました。これらの成果を基に、世界の高病原性鳥インフルエンザと新型ウイルス対策ならびに人獣共通感染症克服のため、広範な研究を展開し、国際協力研究にも多大な寄与をしています。

主要な著書・論文

  1. Yanagihara Y, Villanueva SYAM, Nomura N, Ohno M, Sekiya T, Handabile C, Shingai M, Higashi H, Yoshida SI, Masuzawa T, Gloriani NG, Saito M, Kida H: "Is an Environmental Bacterium That Grows in Waterlogged Soil", Microbiol Spectr: e0215721, 2022.
  2. Handabile C, Sekiya T, Nomura N, Ohno M, Kawakita T, Shingai M, Kida H: Inactivated Whole Virus Particle Influenza Vaccine Induces Anti-Neuraminidase Antibodies That May Contribute to Cross-Protection against Heterologous Virus Infection. Vaccines (Basel). 10(5):804, 2022.
  3. Shiohara M, Suzuki S, Shichinohe S, Ishigaki H, Nakayama M, Nomura N, Shingai M, Sekiya T, Ohno M, Iida S, Kawai N, Kawahara M, Yamagishi J, Ito K, Mitsumata R, Ikeda T, Motokawa K, Sobue T, Kida H, Ogasawara K, Itoh Y: Inactivated whole influenza virus particle vaccines induce neutralizing antibodies with an increase in immunoglobulin gene subclones of B-lymphocytes in cynomolgus macaques. Vaccine. S0264-410X(22)00640-5, 2022.
  4. Toba S, Sato A, Kawai M, Taoda Y, Unoh Y, Kusakabe S, Nobori H, Uehara S, Uemura K, Taniguchi K, Kobayashi M, Noshi T, Yoshida R, Naito A, Shishido T, Maruyama J, Paessler S, Carr MJ, Hall WW, Yoshimatsu K, Arikawa J, Matsuno K, Sakoda Y, Sasaki M, Orba Y, Sawa H, Kida H: Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses. Proc Natl Acad Sci USA. 119(36): e2206104119, 2022.
  5. Chua BY, Sekiya T, Ohno M, Koutsakos M, Nomura N, Rowntree LC, Nguyen TH, McQuilten HA, Ohno M, Ohara Y, Nishimura T, Endo M, Itoh Y, Habel J.R, Selva K.J, Wheatley A.K, Wines B.D, Hogarth P.M, Kent S.J, Chung A.M, Jackson D.C, Brown L.E, Shingai M, Kedzierska K, Kida H: Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques. PLoS Pathog 18(10): e1010891, 2022.
  6. Ohno M, Sagata M, Sekiya T, Nomura N, Shingai M, Endo M, Kimachi K, Suzuki S, Nguyen CT, Nakayama M, Ishigaki H, Ogasawara K, Itoh Y, Kino Y, Kida H: Assessing the pyrogenicity of whole influenza virus particle vaccine in cynomolgus macaques. Vaccine. 41: 787-794, 2022.
  7. Hayashida K, Garcia A, Moonga LC, Sugi T, Takuya K, Kawase M, Kodama F, Nagasaka A, Ishiguro N, Takada A, Kajihara M, Nao N, Shingai M, Kida H, Suzuki Y, Hall WW, Sawa H, Yamagishi J: Field-deployable multiplex detection method of SARS-CoV-2 and influenza virus using loop-mediated isothermal amplification and DNA chromatography. PLoS One. 18(5): e0285861, 2023.
  8. Ohno M, Gowda SGB, Sekiya T, Nomura N, Shingai M, Hui SP, Kida H: The elucidation of plasma lipidome profiles during severe influenza in a mouse model. Sci Rep. 13(1):14210, 2023.
  9. Uemura K, Nobori H, Sato A, Toba S, Sasaki M, Tabata K, Matsuno K, Maeda N, Ito S, Tanaka M, Anraku Y, Kita S, Ishii M, Kanamitsu K, Oraba Y, Matsuura Y, Hall W.W, Sawa H, Kida H, Matsuda A, Maenaka K. (2023) 2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses. Proc Natl Acad Sci USA.120(42): e2304139120, 2023.
  10. Shingai M, Nomura N, Sekiya T, Ohno M, Fujikura D, Handabile C, Omori R, Ohara Y, Nishimura T, Endo M, Kimachi K, Mitsumata R, Ikeda T, Kitayama H, Hatanaka H, Sobue T, Muro F, Suzuki S, Thanh Nguyen C, Ishigaki H, Nakayama M, Mori Y, Itoh Y, Koutsakos M, Chua B.Y, Kedzierska K, Brown L.E, Jackson D.C, Ogasawara K, Kino Y, Kida H: Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells. Vaccine. 39: 3940-3951, 2021.
  11. Nomura N, Matsuno K, Shingai M, Ohno M, Sekiya T, Omori R, Sakoda Y, Webster RG, Kida H: Updating the influenza virus library at Hokkaido University -It's potential for the use of pandemic vaccine strain candidates and diagnosis. Virology. 557:55-61, 2021.
  12. Ohno M, Kakino A, Sekiya T, Nomura N, Shingai M, Sawamura T, Kida H: Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model. Sci Rep. 3;11(1):15675, 2021.
  13. Ohno M, Sekiya T, Nomura N, Daito TJ, Shingai M, Kida H: Influenza virus infection affects insulin signaling, fatty acid-metabolizing enzyme expressions, and the tricarboxylic acid cycle in mice. Sci Rep. 2;10: 10879, 2020.
  14. Uehara T, Hayden FG, Kawaguchi K, Omoto S, Hurt AC, DeJong MD, Hirotsu N, Sugaya N, Lee N, Baba K, Shishido T, Tsuchiya K, Portsmouth S, Kida H: Treatment-Emergent Influenza Variant Viruses with Reduced Baloxavir Susceptibility: Imapact on Clinical and Virologic Outcomes in Uncomplicated Influenza. The J Infect Dis. 221(3):346-355, 2019.
  15. Taniguchi K, Ando Y, Nobori H, Toba S, Noshi T, Kobayashi M, Kawai M, Yoshida R, Sato A, Shishido T, Naito A, Matsuno K, Okamatsu M, Sakoda Y, Kida H:   Inhibition of avian-origin influenza A(H7N9) virus by the novel cap-dependent endonuclease inhibitor baloxavir marboxil. Sci Rep. 5; 9:3466, 2019.
  16. Sekiya T, Mifsud EJ, Ohno M, Nomura N, Sasada M, Fujikura D, Daito T, Shingai M, Ohara Y, Nishimura T, Endo M, Mitsumata R, Ikeda T, Hatanaka H, Kitayama H, Motokawa K, Sobue T, Suzuki S, Itoh Y, Brown LE, Ogasawara K, Kino Y, Kida H: Inactivated whole virus particle vaccine with potent immunogenicity and limited IL-6 production is ideal for influenza. Vaccine 37(15):2158-2166, 2019.
  17. Suzuki M, Okamatsu M, Fujimoto Y, Hiono T, Matsuno K, Kida H, Sakoda Y:  Potency of an inactivated influenza vaccine prepared from A/duck/Mongolia/ 245/2015(H10N3) against H10 influenza virus infection in a mouse model. Jpn J Vet Res 66(1):29-41, 2018.
  18. Nakatsukasa A, Kuruma K, Okamatsu M, Hiono T, Suzuki M, Matsuno K, Kida H, Oyamada T, Sakoda Y: Potency of whole virus particle and split virion vaccines using dissolving microneedle against challenges of H1N1 and H5N1 influenza viruses in mice. Vaccine 35(21):2855-2861, 2017. 
  19. Chu DH, Sakoda Y, Nishi T, Hiono T, Shichinohe S, Okamatsu M, Kida H: Potency of an inactivated influenza vaccine prepared from A/duck/Mongolia /119/2008 (H7N9) against the challenge with A/Anhui/1/2013 (H7N9). Vaccine. 32(28): 3473-3479, 2014.
  20. Hiono T, Okamatsu M, Nishihara S, Takase-Yoden S, Sakoda Y, Kida H: A chicken influenza virus recognizes fucosylated α2,3 sialoglycan receptors on the epithelial cells lining upper respiratory tracts of chickens. Virology. 456-457: 131-138, 2014.
  21. Nishi T, Sakoda Y, Okamatsu M, Kida H: Potency of an inactivated influenza vaccine prepared from A/duck/Hong Kong/960/1980 (H6N2) against a challenge with A/duck/Vietnam/OIE-0033/2012 (H6N2) in mice. Arch Virol 159: 2567-2574, 2014.
  22. Shichinohe S, Okamatsu M, Sakoda Y, Kida H: Selection of H3 avian influenza viruses with SAa2,6Gal receptor specificity in pigs. Virology. 444: 404-408, 2013.
  23. Kuribayashi S, Sakoda Y, Kawasaki T, Tanaka T, Yamamoto N, Okamatsu M, Isoda N, Tsuda Y, Sunden Y, Umemura T, NakajimaN, Hasegawa H, Kida H: Excessive cytokine response to rapid proliferation of highly pathogenic avian influenza viruses leads to fatal systemic capillary leakage in chickens. PLoS One. 8(7), e68375, 2013.
  24. Okamatsu M, Sakoda Y, Hiono T, Yamamoto N, Kida H: Potency of a vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) against A/Narita/1/2009 (H1N1) pandemic influenza virus strain. Virol J 10, 47, 2013. 
  25. Nomura N, Sakoda Y, Soda K, Okamatsu M, Kida H: An H9N2 Influenza Virus Vaccine Prepared from a Non-Pathogenic Isolate from a Migratory Duck Confers Protective Immunity in Mice against Challenge with an H9N2 Virus Isolated from a Girl in Hong Kong. J Vet Med Sci 74(4), 441-447, 2012.
  26. Soda K, Cheng MC, Yoshida H, Endo M, Lee SH, Okamatsu M, Sakoda Y, Wang CH, Kida H: A Low Pathogenic H5N2 Influenza Virus Isolated in Taiwan Acquired High Pathogenicity by Consecutive Passages in Chickens. J Vet Med Sci 73, 767-772. 2011.
  27. Soda K, Asakura S, Okamatsu M, Sakoda Y, Kida H: H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens. Virol J 8, 64, 2011.
  28. Itoh Y, Ozaki H, Ishigaki H, Sakoda Y, Nagata T, Soda K, Isoda N, Miyake T, Ishida H, Okamoto K, Nakayama M, Tsuchiya H, Torii R, Kida H, Ogasawara K:  Subcutaneous inoculation of a whole virus particle vaccine prepared from a non-pathogenic virus library induces protective immunity against H7N7 highly pathogenic avian influenza virus in cynomolgus macaques. Vaccine 28, 780-789, 2010.
  29. Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, Hatta M, Muramoto Y, Tamura D, Sakai-Tagawa Y, Noda T, Sakabe S, Imai M, Hatta Y, Watanabe S, Li C, Yamada S, Fujii K, Murakami S, Imai H, Kakugawa S, Ito M, Takano R, Iwatsuki-Horimoto K, Shimojima M, Horimoto T, Goto H, Takahashi K, Makino A, Ishigaki H, Nakayama M, Okamatsu M, Warshauer D, Shult PA, Saito R, Suzuki H, Furuta Y, Yamashita M, Mitamura K, Nakano K, Nakamura M, Brockman-Schneider R, Mitamura H, Yamazaki M, Sugaya N, Suresh M, Ozawa M, Neumann G, Gern J, Kida H, Ogasawara K, Kawaoka Y: In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 460, 1021-1025, 2009.
  30. Sawai T, Itoh Y, Ozaki H, Isoda N, Okamoto K, Kashima Y, Kawaoka Y, Takeuchi Y, Kida H, Ogasawara K: Induction of cytotoxic T-lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin. Immunology 124, 155-165, 2008. 
  31. Sakabe S, Sakoda Y, Haraguchi Y, Isoda N, Soda K, Takakuwa H, Saijo K, Sawata A, Kume K, Hagiwara J, Tuchiya K, Lin Z, Sakamoto R, Imamura T, Sasaki T, Kokumai N, Kawaoka Y, Kida H: A vaccine prepared from a non-pathogenic H7N7 virus isolated from natural reservoir conferred protective immunity against the challenge with lethal dose of highly pathogenic avian influenza virus in chickens. Vaccine 26, 2127-2134, 2008.
  32. Itoh Y, Ozaki H, Tsuchiya H, Okamoto K, Torii R, Sakoda Y, Kawaoka Y, Ogasawara K, Kida H: A vaccine prepared from a non-pathogenic H5N1 avian influenza virus strain confers protective immunity against highly pathogenic avian influenza virus infection in cynomolgus macaques. Vaccine 26, 562-572, 2008.
  33. Noda T, Sagara H, Yen A, Kida H, Cheng RH, Kawaoka Y: architecture of ribonucleoprotein complexes in influenza A virus particles. Nature 439, 490-492, 2006.
  34. Noda T, Ebihara H, Muramoto Y, Fujii K, Takada A, Sagara H, Kim JH, Kida H, Feldmann H, Kawaoka Y: Assembly and budding of Ebolavirus. PLoS Pathog 2, e99, 2006.
  35. Muramoto Y, Ozaki H, Takada A, Park CH, Sunden Y, Umemura T, Kawaoka Y, Matsuda H, Kida H: Highly pathogenic H5N1 influenza virus causes coagulopathy in chickens. Microbiol Immunol 50, 73-81, 2006.
  36. Kida H, Sakoda Y: Library of influenza virus strains for vaccine and diagnostic use against highly pathogenic avian influenza and human pandemics. Dev Biol (Basel) 124, 69-72, 2006.
  37. Kishida N, Sakoda Y, Eto M, Sunaga Y, Kida H: Co-infection of Staphylococcus aureus or Haemophilus paragallinarum exacerbates H9N2 influenza A virus infection in chickens. Arch Virol 149, 2095-2104, 2004.
  38. Takada A, Matsushita S, Ninomiya A, Kawaoka Y, Kida H: Intranasal immunization with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza A virus infection in mice. Vaccine 21, 3212-3218, 2003.
  39. Ninomiya A, Ogasawara K, Kajino K, Takada A, Kida H: Intranasal administration of a synthetic peptide vaccine encapsulated in liposome together with an anti-CD40 antibody induces protective immunity against influenza A virus in mice. Vaccine 20, 3123-3129, 2002.
  40. Okazaki K, Takada A, Ito T, Imai M, Takakuwa H, Hatta M, Ozaki H, Tanizaki T, Nagano T, Ninomiya A, Demenev VA, Tyaptirganov MM, Karatayeva TD, Yamnikova SS, Lvov DK, Kida H: Precursor genes of future pandemic influenza viruses are perpetuated in ducks nesting in Siberia. Arch Virol 145, 885-893, 2000.
  41. Takada A, Kuboki N, Okazaki K, Ninomiya A, Tanaka H, Ozaki H, Hamura S, Nishimura H, Enami M, Tashiro M, Shortridge KF, Kida H: An avirulent avian influenza virus as a vaccine strain against a potential human pandemic. J Virol 73, 8303-8307, 1999.
  42. Ito T, Couceiro JN, Kelm S, Baum LG, Krauss S, Castrucci MR, Donatelli I, Kida H, Paulson JC, Webster RG and Kawaoka Y: Molecular basis for the generation in pigs of influenza A viruses with pandemic potential. J Virol 72, 7367-7373, 1998.
  43. Ito T, Okazaki K, Kawaoka Y, Takada A, Webster RG, Kida H: Perpetuation of influenza A viruses in Alaskan waterfowl reservoirs. Arch Virol 140, 1163-1172, 1995. 
  44. Kida H, Ito T, Yasuda J, Shimizu Y, Itakura C, Shortridge KF, Kawaoka Y, Webster RG: Potential for transmission of avian influenza viruses to pigs. J Gen Virol 75 (Pt 9), 2183-2188, 1994.
  45. Naruse H, Ogasawara K, Kaneda R, Hatakeyama S, Itoh T, Kida H, Miyazaki T, Good RA, Onoe K: A potential peptide vaccine against two different strains of influenza virus isolated at intervals of about 10 years. Proc Natl Acad Sci U S A 91, 9588-9592, 1994.
  46. Ogasawara K, Naruse H, Itoh Y, Gotohda T, Arikawa J, Kida H, Good RA, Onoe K: A strategy for making synthetic peptide vaccines. Proc Natl Acad Sci USA 89, 8995-8999, 1992.
  47. Yasuda J, Shortridge KF, Shimizu Y, Kida H: Molecular evidence for a role of domestic ducks in the introduction of avian H3 influenza viruses to pigs in southern China, where the A/Hong Kong/68 (H3N2) strain emerged. J Gen Virol 72 (Pt 8), 2007-2010, 1991.    
  48. Kida H, Shortridge KF, Webster RG: Origin of the hemagglutinin gene of H3N2 influenza viruses from pigs in China. Virology 162, 160-166, 1988.
  49. Kida H, Kawaoka Y, Naeve CW, Webster RG: Antigenic and genetic conservation  of H3 influenza virus in wild ducks. Virology 159, 109-119, 1987.
  50. Yoden S, Kida H, Kuwabara M, Yanagawa R, Webster RG: Spin-labeling of influenza virus hemagglutinin permits analysis of the conformational change at low pH and its inhibition by antibody. Virus Res 4, 251-261, 1986.
  51. Yoden S, Kida H, Yanagawa R: Is bivalent binding of monoclonal antibodies to different antigenic areas on the hemagglutinin of influenza virus required for neutralization of viral infectivity? Arch Virol 85, 209-216, 1985.
  52. Shimizu K, Mukaigawa J, Oguro M, Ono Y, Nakajima K, Kida H: Inhibition of transcriptase activity of influenza A virus in vitro by anti-haemagglutinin antibodies. Vaccine 3, 207-210, 1985.
  53. Kida H, Yoden S, Kuwabara M, Yanagawa R: Interference with a conformational change in the haemagglutinin molecule of influenza virus by antibodies as a possible neutralization mechanism. Vaccine 3, 219-222, 1985.
  54. Okazaki K, Yanagawa R, Kida H: Contact infection of mink with 5 subtypes of avian influenza virus. Arch Virol 77, 265-269, 1983.
  55. Yoden S, Kida H, Yanagawa R: An avian influenza virus of which   infectivity is neutralized by antisera lacking hemagglutination-inhibition activity. Arch Virol 74, 205-210, 1982.
  56. Kida H, Brown LE, Webster RG: Biological activity of monoclonal antibodies to operationally defined antigenic regions on the hemagglutinin molecule of A/Seal/Massachusetts/1/80 (H7N7) influenza virus. Virology 122, 38-47, 1982.
  57. Kida H, Yanagawa R, Matsuoka Y: Duck influenza lacking evidence of disease signs and immune response. Infect Immun 30, 547-553, 1980.        
  58. Kida H, Yanagawa R: Isolation and characterization of influenza A viruses from wild free-flying ducks in Hokkaido, Japan. Zntbl Bakteriol Orig A 244,135-143, 1979.
  59. 喜田　宏: インフルエンザ. 木村哲, 喜田宏（編）, 人獣共通感染症 pp54-59, 2004. 改訂版 pp72-80, 2011. 改訂３版 pp71-82, 2016. 医薬ジャーナル社（大阪, 東京）.

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